Given the current evidence regarding the potential implication of angiotensin-related signaling cascade in COVID-19 [18, 19], we investigate the association between AGT rs699 C > T, ACE rs4646994 indel, and AGTR1 rs5186 C > A variants and the risk of COVID-19 infection in a sample of the southeast Iranian population. This evidence concerns the gene AGTR1 and COVID-19.