Early studies showed that poly(I:C) was able to stimulate IL-12 production with subsequent NK cell activation and improved IFN-γ production [45], and that cytokines secreted by NKL-IL15 cells, including IFN-γ, could induce the expression of NKG2D ligands on target cells and thus increase the susceptibility of leukemia cells to NK cell-mediated cytolysis [23]. This evidence concerns the gene IFNG and leukemia.