APOE and triple-A syndrome: We used a murine model of AAA development based on angiotensin II (Ang II) infusion in double apolipoprotein E- and Mfap4-deficient (ApoE−/−Mfap4−/−) mice and control apolipoprotein E-deficient (ApoE−/−) littermates as well as cell culture studies to establish a mechanistic role of MFAP4 in AAA pathophysiology.