Further, it has also been observed that the expression levels of HOTAIRM1, HOXA10-AS, HOXA10-AS, HOXA11-AS, HOXA-AS2, HOXA-AS3, HOXB-AS1, HOXC13-AS, HOXC-AS3, and HOXD-AS2 are upregulated in glioma, and are positively correlated with malignancy (Li et al., 2017; Li et al., 2020a), and importantly, some studies have shown that HOXATs can play fundamental roles in immune system regulation (Li et al., 2020b; Liang et al., 2020). This evidence concerns the gene HOXA10 and central nervous system cancer.