Meanwhile, the co-expression of HOXATs in immune checkpoints and immune cells across 33 different cancer types indicated that the expression levels of HOXATs, such as HOXB-AS1, HOXC-AS2, HAGLR, HOTAIR, and HOTAIRM1 are significantly positively correlated with the expression of CTLA-4, PD-L1, and other immunocyte markers as well as immune cells, such as resting T cells, NK cells, eosinophils, and mast cells. Here, CD274 is linked to cancer.