Expression of FGF15/19 is strongly induced by farnesoid X receptor (FXR) in the ileum, and the protein is secreted into the portal blood and transported to the liver, where it represses the expression of CYP7a1, a rate-limiting enzyme in bile acid synthesis, thereby mitigating liver fibrosis (Inagaki et al., 2005; Liu et al., 2020b). Here, NR1H4 is linked to Hepatic fibrosis.