PTGIS and Hepatic fibrosis: DNMT1 and DNMT3B methylates the genes encoding regulator of calcineurin 1 (RCAN1), prostacyclin synthase (PTGIS), Septin9 and SAD1/UNC84 domain protein-2 (SUN2), promoting HSC activation and liver fibrosis (Wu et al., 2017; Chen et al., 2018; Pan et al., 2018; Pan et al., 2019).