Binding of anti-Gal to inserted α-gal glycolipids initiates uptake of tumor cells and cell membranes by APCs, followed by effective activation of tumor-specific CD4+ and CD8+ T cells and destruction of injected tumors and of distant metastases (Galili et al., 2007; Abdel-Motal et al., 2009b). Here, CD4 is linked to neoplasm.