ENPP2 and Hodgkins lymphoma: Besides, in Hodgkin lymphoma, high levels of ENPP2 are strongly positivity associated with Epstein-Barr virus (EBV), EBV infection results in the induction of ENPP2 and leads to the enhanced growth and survival of Hodgkin lymphoma cells via the ENPP2/LPA axis (Baumforth et al., 2005).