A role of dysfunctional ASPP2 in human neoplasms has been suggested by the observation that ASPP2 is downregulated in several tumor types, including human acute leukemia (Schittenhelm et al., 2013), choriocarcinoma (Mak et al., 2013), pancreatic cancer (Song et al., 2015) and diffuse large B-cell lymphoma (Lossos et al., 2002). This evidence concerns the gene TP53BP2 and pancreatic neoplasm.