A role of dysfunctional ASPP2 in human neoplasms has been suggested by the observation that ASPP2 is downregulated in several tumor types, including human acute leukemia (Schittenhelm et al., 2013), choriocarcinoma (Mak et al., 2013), pancreatic cancer (Song et al., 2015) and diffuse large B-cell lymphoma (Lossos et al., 2002). The gene discussed is TP53BP2; the disease is familial pancreatic carcinoma.