It was reported that Ca2+ is associated with EGFR in NSCLC and HNSCC cells (Wang et al., 2017; Kim et al., 2020), and an increase in intracellular Ca2+ levels could activate the ERK pathway (Ayush et al., 2016; Wang et al., 2019). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.