Furthermore, the upregulation of ACE2, in patients with severe symptoms of COVID-19 (45), increases Angiotensin 1–9 levels that in turn rise the levels of BK in the cells (referred to as a “Bradykinin Storm”), comporting a dysregulated BK signaling in COVID-19 patients (51) with further TRPV-1 sensitization. The gene discussed is KNG1; the disease is COVID-19.