EGFR and non-small cell lung carcinoma: Thereafter, all the significant factors from univariate analysis (P < 0.05) were included in the multivariate Cox analysis, which showed that age, serum LDH, serum Cyfra211, EGFR mutation, and Ki-67 were independent prognostic factors associated with first-line therapeutic in NSCLC patients (P < 0.05; Table 3).