Second, to investigate the difference between serum SHBG concentrations and the ovarian response between non-PCOS and PCOS subgroups, we strictly limited the treatment protocol as well as patient age, AMH, and other variables; however, possible effects on serum SHBG concentrations caused by age, treatment protocol, or the cause of infertility cannot be ruled out. The gene discussed is AMH; the disease is Infertility.