ROC analysis of hCG-day SHBG in non-PCOS and PCOS subgroups showed that the AUCROC in non-PCOS and PCOS participants were 0.7450 and 0.5497, respectively (P = 0.0015 and 0.5142) (Figures 3B,C). The gene discussed is SHBG; the disease is polycystic ovary syndrome.