EIF4E and cystic kidney disease: While OFD1 weakly binds mRNA, the presence of BICC1, an RNA-binding protein also found at the centrosome, allows OFD1 to mediate a stronger association between eIF4F via eIF4E and several centrosomal mRNAs that are implicated in ciliogenesis and renal cyst formation (Iaconis et al., 2017).