miR-589-5p is a well-established cancer-associated miRNA, found to inhibit MAP3K8 in hepatocellular carcinoma (Zhang et al., 2016), regulate tumor growth in HCC by targeting MIG-6 (Xu et al., 2018), and act as tumor suppressor in prostate cancer (Ji et al., 2019). This evidence concerns the gene MAP3K8 and hepatocellular carcinoma.