In Axis 4 (Table 1), miR-493-5p↓ ZIC2↑ MBNL2↑, MBNL2 is abnormally expressed in lung and breast cancer (Zhang J. et al., 2019), as well as hepatocellular carcinoma (Lee et al., 2016). This evidence concerns the gene MBNL2 and hepatocellular carcinoma.