Given that other various GTPases are well known in their regulatory roles in cancer, it is plausible that RPGR is associated with NPC progression (Fernández-Medarde and Santos, 2011; Prieto-Dominguez et al., 2019; Boudhraa et al., 2020; Clayton and Ridley, 2020). This evidence concerns the gene RPGR and nasopharyngeal carcinoma.