Early studies have established that circulating C-reactive protein (CRP) and inflammatory cytokines, such as interleukin-6 (IL-6) are elevated in the peripheral blood of individuals with PCOS (Benson et al., 2008), and new evidence reveals that chronic low-grade inflammation underlies the disorder’s development of metabolic abnormalities and ovarian dysfunction (González et al., 2006; Farrell and Antoni, 2010; Gonzalez, 2012). This evidence concerns the gene IL6 and ovarian dysfunction.