Most genes were upregulated in DLBCL, and we also found that among the upregulated PRGs, PYCARD, IRF1, GZMA, GSDMD, GSDMC, GPX4, CHMP2A, CASP5, CASP1, IL-18, and BAK1 showed an amplified CNV status, suggesting a significant relationship between the PRG expression and CNV. Here, GPX4 is linked to diffuse large B-cell lymphoma.