BCR and diffuse large B-cell lymphoma: We similarly observed significant oxidative phosphorylation, high activity of the TCA cycle and fatty acid metabolism enrichment in cluster B, findings similar to those observed for OXPHOS-DLBCL by Caro et al. and features that favor the growth and survival of DLBCL and engender resistance to conventional agents that target the BCR signaling axis (Caro et al., 2012).