PARK7 and Parkinson disease: An siRNA-based high content imaging screening was recently performed to identify genes playing a role in the mechanical properties of mitotic cells and one of the top hits was the Parkinson associated gene DJ-1/PARK7 (Toyoda et al., 2017), whose Parkinson-associated mutations are known to result in excessively fragmented mitochondria through DRP1 upregulation and increased vulnerability to oxidative stress in neuronal cells (Wang et al., 2012).