An siRNA-based high content imaging screening was recently performed to identify genes playing a role in the mechanical properties of mitotic cells and one of the top hits was the Parkinson associated gene DJ-1/PARK7 (Toyoda et al., 2017), whose Parkinson-associated mutations are known to result in excessively fragmented mitochondria through DRP1 upregulation and increased vulnerability to oxidative stress in neuronal cells (Wang et al., 2012). The gene discussed is DNM1L; the disease is Parkinsonism.