GISTs harboring the same KIT/PDGFRA mutations often display different malignant features and response to therapy, suggesting that there are other potential GIST-related genes that influence the biological phenotypes or prognosis of GIST patients (Li and Raut, 2019); however, little is known about the mutation profiles at the genome level in GIST. This evidence concerns the gene KIT and gastrointestinal stromal tumor.