It is rare that a GIST tumor harbors mutations in both KIT and PDGFRA, simultaneously; however, one GIST case (S09) carries two GIST driver mutations located in exon 11 of KIT (c.T1676C, p.V559A) and in exon 18 of PDGFRA (c.A2525T, p.D842V). Here, PDGFRA is linked to gastrointestinal stromal tumor.