BRCA1 and gastrointestinal stromal tumor: In this study, in addition to two novel SNVs, BRCA1 p.Y809H (3/49) and BRCA2 p.Y57*(1/49), a known pathologic SNV of BRCA2 (c.3396delA, p.K1132Nfs) (Hereditary cancer-predisposing syndrome) was also identified in 44.91% (22/49) of GIST tumors (Supplementary Table S6).