Chemoresistance through accelerated cell cycle processes was also credited to the activation of NF-κB, a downstream effector of the PI3K-AKT pathway, in several cancers including PDAC (Sui et al., 2014; Hu et al., 2015; Zhu et al., 2015; Eberle, 2019; Liu et al., 2020). This evidence concerns the gene PIK3CA and cancer.