Yang L. et al. (2019) identified the expression of three genes (STK26, KCNT2, CASP12) was correlated with the prognosis of skin cutaneous melanoma (SKCM) using the WGCNA algorithm and LASSO Cox regression model. Another study used network-based co-expression analysis to find 24 hub genes were involved in the immune response and development of metastatic melanoma, and those hub genes can be used as biomarkers for the early diagnosis of melanoma (Wang et al., 2018). Here, CASP12 is linked to metastatic melanoma.