Unexpectedly, the expression profile data showed that the expression of mRNA and protein of BTK was inhibited in LUAD tumor tissue (Figure 6 and Supplementary Figure 5), and the down-regulation of BTK was associated with poor survival, which seemed to contradict the strategy of BTK targeted therapy (Pang et al., 2020; Ramalingam et al., 2020). Here, BTK is linked to neoplasm.