BIK and neoplasm: Binding of stromal type I collagen to DDR1 on tumor cells, triggers a signaling pathway culminating in the transcriptional up-regulation of pro-apoptotic Bcl-2-interacting killer (BIK), promoting cell growth suppression and central mediator of chondrocyte markers type I collagen (COL1)-induced apoptosis (Maquoi et al., 2012; Saby et al., 2019).