Zhai et al. (2016) found that ARID1A loss impaired the formation of ovarian cancer. Mathur et al. (2017) found that ARID1A loss impaired enhancer-mediated gene regulation and drives colon cancer in mice. In the present article, we found that loss of ARID1A expression was associated with a worse outcome for GC patients and was an independent prognostic factor. In line with our results, Kim et al. (2019) demonstrated that loss of ARID1A expression indicated an inferior outcome in GC patients regardless of OS or recurrence-free survival. Here, ARID1A is linked to malignant colon neoplasm.