The consistent lower expression of RETSAT was observed in BRCA (Breast invasive carcinoma), CHOL (Cholangiocarcinoma), COAD (Colon adenocarcinoma), HNSC (Head and Neck squamous cell carcinoma), KICH (Kidney Chromophobe), KIRC (Kidney renal clear cell carcinoma), LUAD (Lung adenocarcinoma), LUSC (Lung squamous cell carcinoma), PCPG (Pheochromocytoma and Paraganglioma), PRAD (Prostate adenocarcinoma), READ (Rectum adenocarcinoma) and THCA (Thyroid carcinoma) compared with the corresponding normal tissues (Figure 1A). The gene discussed is RETSAT; the disease is head and neck squamous cell carcinoma.