Finally, a recent analysis of global transcriptome (RNA-Seq) showed that CRISPR/Cas9 knockout ERK5 human osteosarcoma U2OS cells express elevated levels of CHOP, TRIB3 an XBP-1 mRNAs, compared to wild type U2OS cells (Craig et al., 2020). Here, DDIT3 is linked to osteosarcoma.