Interestingly, the cell lines used in this study present different mutation patterns, including KRAS and TP53 (MiaPaCa-2 pancreatic ductal adenocarcinoma cells), PTEN and TP53 (Ishikawa endometrial adenocarcinoma cells), or TP53 mutations only (Hela cervical carcinoma cells). This evidence concerns the gene PTEN and endometrium adenocarcinoma.