However, it has been reported that Piezo1 could act upstream of YAP in oral squamous cell carcinoma (Hasegawa et al., 2021), We speculate that the hierarchical relationship between PIEZO1 and YAP may be dependent on this cell context, or that there is a positive feedback regulation between PIEZO1 and YAP. The gene discussed is PIEZO1; the disease is oral cavity squamous cell carcinoma.