PIEZO1 and renal fibrosis: To explore whether Piezo1-p38MAPK-YAP signaling pathway play a role in renal fibrosis and block the pathway could provide a potential therapeutic target for postponing the development of renal fibrosis, an animal model of renal fibrosis induced by UUO was established and a loss-of-function experiment was carried out by using shRNA of Piezo1 in UUO mice.