Underlining the relevance of the NLRP3 inflammasome, IL-1β has been associated with disease pathogenesis in multiple PD biomarker studies (Koprich et al., 2008; Su et al., 2008; Nakahira et al., 2011; Gillardon et al., 2012; Pike et al., 2021). The gene discussed is NLRP3; the disease is Parkinson disease.