NLRP3 and obesity due to melanocortin 4 receptor deficiency: Our results evidencing NLRP3 inflammasome activation in the ovaries in early obesity (after 4- week HFD) are in line with previous reports showing the accumulation of proinflammatory mediators in the ovary of mice after short-term (6- week HFD) DIO (Shen et al., 2021).