In early obesity, inflammatory cues in CCs were mediated by the upregulation of genes involved in cellular response to stress as DEAD-box helicase 5 (Ddx5), hypoxia inducible factor 1 subunit alpha (Hif1a), and ADAM metallopeptidase domain 9 (Adam9). The gene discussed is HIF1A; the disease is obesity due to melanocortin 4 receptor deficiency.