Signaling roles for some of these cargoes in NASH include microRNAs (miR-128-3p), lipids (sphingosine 1-phosphate), and proteins (CXCL10, Vanin) (Povero et al., 2013; Povero et al., 2015; Ibrahim et al., 2016; Liao et al., 2018). The gene discussed is CXCL10; the disease is metabolic dysfunction-associated steatohepatitis.