Furthermore, we found that ITGB3 transcriptional level in kidneys was significantly associated with the baseline eGFR based on Nephroseq database in DN, LN, and FSGS patients, while not in MN and MCD patients (Woroniecka et al., 2011; Berthier et al., 2012; Ju et al., 2015; Figure 4L and Supplementary Figures 4A–D). This evidence concerns the gene ITGB3 and focal segmental glomerulosclerosis.