As shown by Masson trichrome staining and SA-β-gal, F4/80, and Fn1 staining of mouse renal tissues (Figures 5B–E), delivery of Itgb3-expressing plasmid significantly promoted the tubulointerstitial fibrosis, the infiltration of inflammatory cells, and cellular senescence after UUO. Here, FN1 is linked to fibrosis.