These deregulated genes were applied for DAVID KEGG signaling enrichment annotation, and 17 were enriched in tumor signaling, including 11 downregulated (EGFR, AXIN2, WNT7B, ADCY1, GNG12, GNAI1, ITGB1, ITGA6, LAMB1, LAMC1, and RUNX1) and 6 upregulated (CXCL8, FOS, MYC, JUN, NFKB2, and TRAF4) by PDT. The gene discussed is JUN; the disease is neoplasm.