Vascular cell adhesion molecule-1 (VCAM-1) is involved in tumor cell adhesion and metastasis (Yin et al., 2017), and matrix metalloproteinases (MMPs) are responsible for the angiogenesis and metastasis (Danhier et al., 2010; Liu T. W. et al., 2016), RGD ligands are another frequently used target and the recognition is via αvβ3 integrin (Yuan et al., 2014). Here, VCAM1 is linked to neoplasm.