This research is very promising, especially considering that the anti-tumor activity of lapatinib was also observed in human bladder cancer cell lines (McHugh et al., 2009), wherein it exhibited overexpression of HER2 determined by an immunochemistry range from 8% up to 80% (Jimenez et al., 2001; Powles et al., 2017). Here, ERBB2 is linked to urinary bladder cancer.