Severe background abnormalities with burst suppression on EEG and refractory seizures in a neonate with encephalopathy of unknown etiology suggest a diagnosis of epileptic encephalopathy with likely genetic cause; mutations in the KCNQ2 gene are the most common cause of neonatal onset genetic epilepsy and epileptic encephalopathy (17–19). Here, KCNQ2 is linked to Epileptic encephalopathy.