Collectively, microglia can be activated by LPS or cytokines such as TNF-α and IL-6, and destroy the BBB during the initial phase of sepsis by directly mediating neuroinflammation in the brain and participating in the direct spread of neuroinflammation in the course of SAE (Hawkins and Davis, 2005; Ronaldson and Davis, 2020). This evidence concerns the gene TNF and Sepsis.