Omi/high-temperature requirement serine protease A2 (HtrA2), a proapoptotic serine protease mainly found in and released from mitochondria, is found to be involved in the development of BBB dysfunction and SAE induced by sepsis through a caspase-dependent mitochondrial pathway (Wang et al., 2018; Hu et al., 2019). This evidence concerns the gene HTRA2 and Sepsis.