To understand if the difference of CXCL16 regulation in the murine brain appears due to differences of RABV strains or rather differences in the human versus murine model, we infected different human and murine CNS cell lines with the same RABV Tha isolate previously used for animal infections and evaluated the expression level of CXCL16 at 48 hours post-infection. The gene discussed is CXCL16; the disease is infection.