Upon activation with IL-12, NK cells secrete IFN-γ, leading to the elimination of bacterial infections including those caused by Y. enterocolitica, S. typhimurium, and L. monocytogenes, as well as stimulation with LPS (Hunter et al., 1995; Bohn and Autenrieth, 1996; Mastroeni et al., 1996; van de Wetering et al., 2009). Here, IFNG is linked to bacterial infectious disease.