In terms of the regulation of NF-κB pathway in HCC, a study has demonstrated that the upregulation of lnc Myd88 in HCC contributes to the enrichment of acetylation of H3K27 at the promoter of Myd88, which promotes the transcription of Myd88 and then activates the NF-κB signaling pathway (85). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.