Herein, we put a particularly focus on up-to-date findings regarding the role of ncRNAs in NF-κB signaling of HCC (Figure 1), then discuss the potential significance of ncRNAs in overcoming the obstacle of NF-κB-associated chemoresistance in HCC, finally future research directions and challenges are addressed. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.