Subset #1 cases display a unique transcriptional profile even when compared with other CLL cases with concordant SHM status: differentially expressed genes are implicated in apoptosis (e.g., ATM, PARP1), cell proliferation (e.g., KRAS), and oxidative processes favoring the survival of CLL cells (39). The gene discussed is KRAS; the disease is B-cell chronic lymphocytic leukemia.