SF3B1 and B-cell chronic lymphocytic leukemia: Regarding the genetic landscape, CLL cases assigned to stereotyped #6 display low frequency of TP53 mutations (4%), low-to-intermediate frequency of SF3B1 mutations (13%) and, in contrast, high frequency of NOTCH1 mutations (22%) which, interestingly, was not accompanied by trisomy 12 in almost none of the cases (41).