From a different perspective, subset #8 cases display excessive (promiscuous) antigen reactivity as the corresponding BcR IG, expressed as recombinant monoclonal antibodies (rmAbs), bound a plethora of antigens, including autoantigens and neo-epitopes, in contrast with other aggressive CLL subsets, namely #1 and #2, that did not exhibit such polyreactivity (27). The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.