In this study, we comprehensively analysed the similarities in mutational status in a series of 93 tumours from 42 patients with surgically resected synchronous multiple primary lung adenocarcinomas, such as SNV, Indel mutations of EGFR, ALK, KRAS, BRAF, ERBB2, PIK3CA, and TP53, fusion mutations of ALK, ROS1, RET genes, MET jumping mutations and copy number variation of ERBB2, MET genes. The gene discussed is TP53; the disease is lung adenocarcinoma.