The direct killing effect via tumor-targeted CEVs combined chemotherapeutic drugs (19, 21–23, 25, 51, 65–67)Increased brogation of tumor-repopulating cells (18)The increased reactive oxygen species (ROS)and neutrophil extracellular trap (NET) in tumor area (18)The increaed release of IL-2 and IFN-Ɣ and reduce of CDI67+ macrophagesin malignant pleual effusion (25). This evidence concerns the gene IFNA1 and neoplasm.