Because NRN1 expression is positively associated with the proliferation of patient-derived TGCT spheroid cultures with cancer stemness features, we here extend our question whether NRN1 contributes to the proliferation of RCC cells, particularly in clear cell carcinoma where HIF1α signaling is predominantly activated due to mutational inactivation of VHL. This evidence concerns the gene HIF1A and renal cell carcinoma.