In RNA-seq dataset of TCGA RCC cohort (n = 845), patients with high NRN1 mRNA levels had shorter overall survival rate than those with low NRN1 levels (expression level range: 0.1-204.2 FPKM, expression median level: 2.9, expression cut off level 6.6 FPKM, P = 3.4e-4) (Figure 1C). This evidence concerns the gene NRN1 and renal cell carcinoma.