CXCR4 and renal cell carcinoma: In RNA-seq dataset of TCGA RCC cohort (n = 845), patients with high CXCR4 mRNA levels had shorter overall survival rate than those with low CXCR4 levels (expression level range: 2.1-372.0 FPKM, expression median level: 61.8, expression cut off level: 99.5 FPKM, P = 1.1e-5) (Supplementary Figure 5E).