RBMY may regulated genes that involved in various cell proliferative pathways, such as the RAS/RAF/MAP and PIP3/AKT signaling pathways.Y‐linked RBMY could serve dual tumor‐suppressing and tumor‐promoting functions, depending on the spatiotemporal and magnitude of its expression during oncogenic processes, thereby contributing to sexual dimorphisms in liver cancer. This evidence concerns the gene AKT1 and neoplasm.