Among them, the expression of RBM15, VIRMA, HNRNPA2B1, and YTHDF1/2/3 were significantly upregulated, but METTL3, METTL14, METTL16, WTAP, FTO, YTHDC1, and EIF3A had lower expression in breast cancer compared to normal samples (Figures 2A, B). The gene discussed is METTL3; the disease is breast carcinoma.