Although these studies have achieved a lot of significant findings, there is considerable overlap between subtypes, and to date, no studies to my knowledge have shown the usefulness of receptor (ER [estrogen receptor], PR [progesterone receptor]) status of breast malignancy in the interpretation of 18F-FDG PET/CT, not to mention the proportion of the receptors expression in tumor cells. This evidence concerns the gene ESR1 and neoplasm.