As for IGF-1R, the top 3 negatively enriched KEGG terms were WNT signaling pathway, chronic myeloid leukemia, and adherens junction (Figure 8E), and the top positively enriched KEGG terms were intestinal immune network for IgA production, type I diabetes mellitus, allograft rejection, and graft-versus-host disease (Figure 8F). This evidence concerns the gene IGF1R and graft versus host disease.