The result showed that the expression level of NLRP1, NOD1, PLCG1, PLCG1, GSDMB, NLRP6, GSDMC, NLRP7, IL1B, GSDMA, CASP3, NLRRC4MNLRP3, CASP8, CASP1, CASP4, CASP5, AIM2, NOD2, GPX4, GSDMD, PYCARD, and IL18 in the ccRCC tissues was higher than that in the normal renal tissues, while the expression level of genes containing CASP9 and NLRP2 in the normal renal tissues was higher than that in the ccRCC tissues (Figure 1A). This evidence concerns the gene GSDMD and nonpapillary renal cell carcinoma.