Regarding the DU 145 xenografts, although an increase in the number of cleaved caspase-3 positive tumor cells was detected in response to perifosine treatment, there were no obvious differences in the morphological observations, staining patterns of Ki-67, and van Gieson staining between the control and perifosine groups (Table 3 and Figures 5A–J). Here, CASP3 is linked to neoplasm.