Finally, we confirmed that the suppression level of H1915-tumor growth was associated with the high accumulation of perifosine at the tumor site and the resultant blockage of the PI3K/Akt signaling pathway, decrease in tumor cell proliferation, and increased apoptosis; these findings suggested that these are all indispensable events underlying the in vivo antitumor activity of perifosine. This evidence concerns the gene AKT1 and neoplasm.