Perifosine exhibited a marked decrease in tumor cell proliferation, as detected by Ki-67 and increased apoptosis (cleaved caspase-3 staining), compared to that in tumor cells from the control group, and the majority of the residual tumor tissues treated with perifosine were composed largely of collagen fibers (van Gieson) and well-formed granulomas, which are thought to be formed by the effect of perifosine (Table 3 and Figures 5K–T). This evidence concerns the gene CASP3 and neoplasm.