FANCC and Splenomegaly: Moribund Fancc-/-;Mad2+/- mice exhibited extensive bone marrow infiltrates, peripheral cytopenia (10/10 examined mice), lymphadenopathy, splenomegaly with disrupted splenic architecture (8/10), and widespread hematopoietic infiltrates in the livers and other organs (8/10) (Figures 1L, M and Supplemental Figures 2A–G).