All mice transplanted with leukemic Fancc-/-;Mad2+/- marrows for which engraftment was confirmed by CD45.2+ LDMNCs in peripheral blood (recipients of 4/5 donor mice) had leukemia at necropsy one-year after transplant (Figure 2B), and 5/13 recipients of Fancc-/-;Mad2+/- leukemic marrows died within one-year post-HSCT (Figure 2C). The gene discussed is FANCC; the disease is leukemia.