RUNX1 and acute myeloid leukemia: Remarkably, when analyzing the NGS data for these cases, the cases closer to the t(8;21) AML group were found to harbor a somatic mutations clustering within the Runt domain (RUNX1-mutated AML cases: 36, 53, and 66; RUNX1 nonmutated AML cases: 11, 35, and 74; Table S1).